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Nonlinear Analysis of the BOLD Signal


The linearized filtering approach to the hemodynamic system is limited in capturing the inherent nonlinearities of physiological systems. The nonlinear estimation method therefore should be thought of as a natural way to access the nonlinear data assimilation problem. In this paper, we present a nonlinear filtering algorithm which is computationally expensive compared to the existing linearization filtering algorithms, for hemodynamic data assimilation, to address the deficiencies inherent to linearization. Simultaneous estimation of the physiological states and the system parameters have been demonstrated in a simulated and real data. The method provides more reasonable inference about the parameters of models for hemodynamic data assimilation.

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Correspondence to Pengcheng Shi.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, Z., Zhao, X., Liu, H. et al. Nonlinear Analysis of the BOLD Signal. EURASIP J. Adv. Signal Process. 2009, 215409 (2009).

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