Skip to main content
Figure 1 | EURASIP Journal on Advances in Signal Processing

Figure 1

From: Novel Data Fusion Method and Exploration of Multiple Information Sources for Transcription Factor Target Gene Prediction

Figure 1

Illustration of data fusion problem in TF target gene prediction. The promoter sequence names are shown above the arrow, and the arrow corresponds to transcription start site (TSS). Horizontal axis corresponds to position relative to TSS. The red bar(s) together with a TF name on the first line of each figure represent the known binding site. For a given TF, data shown in grey (named with TRANSFAC IDs) represent models corresponding to different position-specific frequency matrices (PSFM) that are found from the TRANSFAC database. Evolutionary conservation (green), regulatory potential (blue), two nucleosome positioning signals [1, 2] (magenta), and DNA duplex stability data (red) are shown in the following five rows (abbreviated with con., reg., npy., nuc. and DNA., resp.). The joint prior from all the four additional data sources (black) is shown in the last row. TFs shown in panels (a) and (b) are assumed to bind to their corresponding sequences in a double-strand manner, while TFs in panels (c) and (d) bind in a single-strand manner. All plotted data are for mouse genome.

Back to article page