Open Access

Time-Frequency Characterization of Cerebral Hemodynamics of Migraine Sufferers as Assessed by NIRS Signals

  • Filippo Molinari1Email author,
  • Samanta Rosati1,
  • William Liboni2,
  • Emanuela Negri2,
  • Ornella Mana2,
  • Gianni Allais3 and
  • Chiara Benedetto3
EURASIP Journal on Advances in Signal Processing20102010:459213

https://doi.org/10.1155/2010/459213

Received: 31 December 2009

Accepted: 24 June 2010

Published: 13 July 2010

Abstract

Near-infrared spectroscopy (NIRS) is a noninvasive system for the real-time monitoring of the concentration of oxygenated ( ) and reduced (HHb) hemoglobin in the brain cortex. and HHb concentrations vary in response to cerebral autoregulation. Sixty-eight women (14 migraineurs without aura, 49 migraineurs with aura, and 5 controls) performed breath-holding and hyperventilation during NIRS recordings. Signals were processed using the Choi-Williams time-frequency transform in order to measure the power variation of the very-low frequencies (VLF: 20–40 mHz) and of the low frequencies (LF: 40–140 mHz). Results showed that migraineurs without aura present different LF and VLF power levels than controls and migraineurs with aura. The accurate power measurement of the time-frequency analysis allowed for the discrimination of the subjects' hemodynamic patterns. The time-frequency analysis of NIRS signals can be used in clinical practice to assess cerebral hemodynamics.

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Authors’ Affiliations

(1)
Biolab, Department of Electronics, Polytechnic of Turin
(2)
Department of Neuroscience, Gradenigo Hospital
(3)
Women's Headache Center, Department of Gynecology and Obstetrics, University of Torino

Copyright

© Filippo Molinari et al. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.