TY - JOUR AU - Spirov, Alexander AU - Holloway, David M. PY - 2003 DA - 2003/07/21 TI - Evolutionary Techniques for Image Processing a Large Dataset of Early Drosophila Gene Expression JO - EURASIP Journal on Advances in Signal Processing SP - 975423 VL - 2003 IS - 8 AB - Understanding how genetic networks act in embryonic development requires a detailed and statistically significant dataset integrating diverse observational results. The fruit fly (Drosophila melanogaster) is used as a model organism for studying developmental genetics. In recent years, several laboratories have systematically gathered confocal microscopy images of patterns of activity (expression) for genes governing early Drosophila development. Due to both the high variability between fruit fly embryos and diverse sources of observational errors, some new nontrivial procedures for processing and integrating the raw observations are required. Here we describe processing techniques based on genetic algorithms and discuss their efficacy in decreasing observational errors and illuminating the natural variability in gene expression patterns. The specific developmental problem studied is anteroposterior specification of the body plan. SN - 1687-6180 UR - https://doi.org/10.1155/S1110865703302069 DO - 10.1155/S1110865703302069 ID - Spirov2003 ER -