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Genomic Signals of Reoriented ORFs

Abstract

Complex representation of nucleotides is used to convert DNA sequences into complex digital genomic signals. The analysis of the cumulated phase and unwrapped phase of DNA genomic signals reveals large-scale features of eukaryote and prokaryote chromosomes that result from statistical regularities of base and base-pair distributions along DNA strands. By reorienting the chromosome coding regions, a "hidden" linear variation of the cumulated phase has been revealed, along with the conspicuous almost linear variation of the unwrapped phase. A model of chromosome longitudinal structure is inferred on these bases.

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Correspondence to Paul Dan Cristea.

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Dan Cristea, P. Genomic Signals of Reoriented ORFs. EURASIP J. Adv. Signal Process. 2004, 804941 (2004). https://doi.org/10.1155/S1110865704309169

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Keywords

  • genomic signals
  • open reading frames
  • ORF orientation