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  • Research Article
  • Open Access

Genomic Signals of Reoriented ORFs

EURASIP Journal on Advances in Signal Processing20042004:804941

Received: 14 March 2003

Published: 21 January 2004


Complex representation of nucleotides is used to convert DNA sequences into complex digital genomic signals. The analysis of the cumulated phase and unwrapped phase of DNA genomic signals reveals large-scale features of eukaryote and prokaryote chromosomes that result from statistical regularities of base and base-pair distributions along DNA strands. By reorienting the chromosome coding regions, a "hidden" linear variation of the cumulated phase has been revealed, along with the conspicuous almost linear variation of the unwrapped phase. A model of chromosome longitudinal structure is inferred on these bases.


genomic signalsopen reading framesORF orientation

Authors’ Affiliations

Biomedical Engineering Center, Politehnica University of Bucharest, Bucharest, Romania


© Dan Cristea 2004