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A Digital Signal Processing Method for Gene Prediction with Improved Noise Suppression

Abstract

It has been observed that the protein-coding regions of DNA sequences exhibit period-three behaviour, which can be exploited to predict the location of coding regions within genes. Previously, discrete Fourier transform (DFT) and digital filter-based methods have been used for the identification of coding regions. However, these methods do not significantly suppress the noncoding regions in the DNA spectrum at. Consequently, a noncoding region may inadvertently be identified as a coding region. This paper introduces a new technique (a single digital filter operation followed by a quadratic window operation) that suppresses nearly all of the noncoding regions. The proposed method therefore improves the likelihood of correctly identifying coding regions in such genes.

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Correspondence to Trevor W. Fox.

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Fox, T.W., Carreira, A. A Digital Signal Processing Method for Gene Prediction with Improved Noise Suppression. EURASIP J. Adv. Signal Process. 2004, 187590 (2004). https://doi.org/10.1155/S1110865704309285

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Keywords

  • gene prediction
  • digital filter
  • DNA
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