Open Access

A Digital Signal Processing Method for Gene Prediction with Improved Noise Suppression

EURASIP Journal on Advances in Signal Processing20042004:187590

https://doi.org/10.1155/S1110865704309285

Received: 1 March 2003

Published: 21 January 2004

Abstract

It has been observed that the protein-coding regions of DNA sequences exhibit period-three behaviour, which can be exploited to predict the location of coding regions within genes. Previously, discrete Fourier transform (DFT) and digital filter-based methods have been used for the identification of coding regions. However, these methods do not significantly suppress the noncoding regions in the DNA spectrum at . Consequently, a noncoding region may inadvertently be identified as a coding region. This paper introduces a new technique (a single digital filter operation followed by a quadratic window operation) that suppresses nearly all of the noncoding regions. The proposed method therefore improves the likelihood of correctly identifying coding regions in such genes.

Keywords

gene prediction digital filter DNA

Authors’ Affiliations

(1)
Research and Development Department, Intelligent Engines Corporation
(2)
Department of Electrical and Computer Engineering, University of Calgary

Copyright

© Fox and Carreira 2004