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  • Research Article
  • Open Access

A Digital Signal Processing Method for Gene Prediction with Improved Noise Suppression

EURASIP Journal on Advances in Signal Processing20042004:187590

  • Received: 1 March 2003
  • Published:


It has been observed that the protein-coding regions of DNA sequences exhibit period-three behaviour, which can be exploited to predict the location of coding regions within genes. Previously, discrete Fourier transform (DFT) and digital filter-based methods have been used for the identification of coding regions. However, these methods do not significantly suppress the noncoding regions in the DNA spectrum at . Consequently, a noncoding region may inadvertently be identified as a coding region. This paper introduces a new technique (a single digital filter operation followed by a quadratic window operation) that suppresses nearly all of the noncoding regions. The proposed method therefore improves the likelihood of correctly identifying coding regions in such genes.


  • gene prediction
  • digital filter
  • DNA

Authors’ Affiliations

Research and Development Department, Intelligent Engines Corporation, 903 42 St. SW, Calgary, Alberta, T3C-1Y9, Canada
Department of Electrical and Computer Engineering, University of Calgary, 2500 University Drive N.W., Calgary, Alberta, T2N 1N4, Canada


© Fox and Carreira 2004