Fig. 3From: Strategies for informed sample size reduction in adaptive controlled clinical trialsThe fitness of the generation in the genetic algorithm-based solution across time. Blue dots shown the fitness (ordinate) of each individual (solution) in a generation (abscissa). The red line shows the variation of the maximal fitness (i.e. the best solution) in a generation and is, by the design of the algorithm, non-decreasingBack to article page