Fig. 4
From: Strategies for informed sample size reduction in adaptive controlled clinical trials
Simulation examples. Shown are the running ground truth of the differential effect (black dotted line), the estimate when the designated number of samples is removed using the proposed pair-wise compatibility-based selection (blue line; see Section 2.2), and the estimate when the designated number of samples is removed using repeated random draws based sample selection (red line; see Section 2.4). The proposed method clearly outperforms the random draws based approach. a Two sample size reductions. b Three sample size reductions